THE family of missing grandmother Jackie Gulliford has appealed for any clues that might help bring her home.

The 61-year-old had last night not been seen since she left her Eynsham home on Tuesday morning.

And her son James Gulliford yesterday told the Oxford Mail his mother seemed to have disappeared without a trace.

The 28-year-old said: “There have not been any leads. It is like she has vanished into thin air.”

Yet he added: “The longer it goes on the harder it starts to feel because you start to run out of places she could be.”

He said his mother – an accounts clerk at the University of Oxford’s Worcester College – had been suffering from depression on and off for about 20 years.

She had recently been treated voluntarily at the Warneford Hospital in Headington and since last week was spending nights at her Hawthorn Road house with her husband Bruce, 63, and receiving hospital care during the day.

The family have put posters up around Eynsham appealing for help.

Mr Gulliford, of Quarry Road in Witney, last night urged for anyone who might have information to call the police on the 101 number.

He said: “Even the smallest thing they might have seen or they might have thought they have seen – it might turn out to be the case-breaker. Even if they are not sure it was her.”

He also thanked the police for their work and all those who had shared the appeal online.

Mrs Gulliford’s daughter Sarah, 31, has two children and also lives in Witney.

Mr Gulliford said police told him officers would be searching around Botley yesterday, where Mrs Gulliford grew up and Wytham Woods where she regularly went for walks.