A 43-year-old Banbury man has not been seen since Saturday evening.
Andy Lever was last seen by his family in Portway and police believe he may have driven his blue Ford Ka to Cambridgeshire.
Thames Valley Police described the missing man as white, about 5ft 10ins tall, with short brown hair.
He has a Japanese symbol tattoo on one arm and a black and red tattoo on the other.
He was last seen wearing a grey t-shirt and black three-quarter length jeans.
Police have said they are concerned for Mr Lever’s welfare due to his state of mind when he went missing.
Anyone with information should call Det Insp Claire Thorngate on 101.