THE A40 was closed yesterday after a crash involving four vehicles.
Thames Valley Police were called to the westbound carriageway of the road near Wolvercote roundabout at around 10.30am.
A white DAF Truck, Ford Transit, Ford Focus car and another vehicle were involved in the collision.
One man was airlifted to the John Radcliffe Hospital with leg injuries, while a woman was taken there with “potentially serious” injuries.
Two others also needed hospital treatment.
Bus services had to be re-routed and traffic backed up during the closure, which lasted for nearly four hours.
A spokesman for South Central Ambulance Service said: “We were called at 10.27am to reports of a road traffic accident involving three cars and a lorry and we sent three ambulances.
“We assessed six patients at the scene and two were assessed but not taken to hospital. Of the four remaining patients, they were all taken to the John Radcliffe Hospital.”
South Central Ambulance had no details of the other two patients who were taken to hospital.
A spokesman for Thames Valley Police said none of the injuries were thought to be fatal.
The incident took place near the Wolvercote roundabout just after the Western Bypass overbridge. Police officers reopened the A40 at around 2pm.
Two fire engines had also been called to the scene to help deal with the incident.
A spokesman for Oxfordshire Fire and Rescue Service said three people had already left their cars but another person had to be cut out of their vehicle.
Stagecoach bus services were affected, the company said, with buses on route S2 being diverted and unable to travel to the Cassington Turn stop.
Passengers travelling on route 18 also experienced delays to their journeys.
The closure meant buses had to travel down Botley Road when entering Oxford.
Buses leaving Oxford were travelling along Woodstock Road to the A44, through Bladon and Long Hanborough, before resuming their normal routes out of the city.
Our top stories: