Police say the A34 northbound is expected to remain closed at the Milton Interchange until about 6.30pm.
Two lorries were involved in a collision which resulted in barrels of beer being spread across the carriageway at around 11.45am.
The drivers of the lorries were taken to the John Radcliffe Hospital with non-life threatening injuries.
One had pelvis and leg injuries and the other was suffering from neck injuries.
Updates will be posted on our Live Traffic Service.