Posters on the windows of Office Outlet on Park End Street, Oxford say the store is closing down.
A member of staff said it is not known when the store will close but it will, unless it is bought out.
The retailer, which was formerly known as Staples, is now connected to the online-only business which currently trades under the Staples name.
Empty shops are on the rise in Oxford with 30 more empty units in the city centre than six months ago.
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